In this introductory article to the special issue on Multi-level semiosis we attempt to stage the background for qualifying the notion of “multi-levelness” when considering communication processes and semiosis in all life forms, i.e. from the cellular to the organismic level. While structures are organized hierarchically, communication processes require a kind of processual organization that may be better described as being heterarchical. Theoretically, the challenge arises in the temporal domain, that is, in the developmental and evolutionary dimension of dynamic semiotic (...) processes. We discuss the importance of this fundamental difference in order to explain how levels, domains and orders of magnitude, on the one hand, and synchronic and diachronic processes, on the other, contribute to the overall organization of every living being. To account for such multi-level organization, semiotic freedom is assumed to be a scalar property that endows living systems at different levels and domains with the capacity to ponder selectively the overall structural coherence and functional compatibility of their heterarchical processing, which is increasingly less conditioned by the underlying molecular determinism. (shrink)

The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...) the number of cell functions they can actually control, both GPCRs and their associated signal transduction pathways are extremely well conserved, for only a few alleles with null or minor functional alterations have so far been found. This would seem to suggest that, beside a mechanism for DNA repairing, there must be another level of quality control that may help maintaining GPCRs rather stable throughout evolution. We propose here receptor oligomerization to be a basic molecular mechanism controlling GPCRs redundancy in many different cell types, and the plasma membrane as the first hierarchical cell structure at which selective categorical sensing may occur. Categorical sensing can be seen as the cellular capacity for identifying and ordering complex patterns of mixed signals out of a contextual matrix, i.e., the recognition of meaningful patterns out of ubiquitous signals. In this context, redundancy and degeneracy may appear as the required feature to integrate the cell system into functional units of progressively higher hierarchical levels. (shrink)

Any living organism interacts with and responds specifically to environmental molecules by expressing specific olfactory receptors. In this paper, this specificity will be first examined in causal terms with particular emphasis on the mechanisms controlling olfactory gene expression, cell-to-cell interactions and odor-decoding processes. However, this type of explanation does not entirely justify the role olfactory receptors have played during evolution, since they are also expressed ectopically in different organs and/or tissues. Homologous olfactory genes have in fact been found in such (...) diverse cells and/or organs as spermatozoa, testis and kidney where they are assumed to act as chemotactic sensors or renin modulators. To justify their functional diversity, homologous olfactory receptors are assumed to share the same basic role: that of conferring a self-identity to cells or tissues under varying environmental conditions. By adopting this standpoint, the functional attribution as olfactory or chemotactic sensors to these receptors should not be seen either as a cause conditioning receptor gene expression, or as a final effect resulting from genetically predetermined programs, but as a direct consequence of the environmental conditions olfactory receptor genes have explored during evolution. The association of odorant patterns with specific environmental or contextual situations makes their relationship semiotically triadic, due to the emergence of an interpretant capable of perceiving odorants as meaningful signs out of a noisy background. This perspective highlights the importance of odorant-receptor relationships as respect to the properties of the interacting partners. It is our contention that only when taken together can these different explanatory strategies provide a realistic account of how olfactory receptor genes have been structurally and functionally modified during evolution. (shrink)

Receptor oligomerization plays a key role in maintaining genome stability and restricting protein mutagenesis. When properly folded, protein monomers assemble as oligomeric receptors and interact with environmental ligands. In a gene-centered view, the ligand specificity expressed by these receptors is assumed to be causally predetermined by the cell genome. However, this mechanism does not fully explain how differentiated cells have come to express specific receptor repertoires and which combinatorial codes have been explored to activate their associated signaling pathways. It is (...) our contention that the plasma membrane acts as the locus where several contextual cues may be integrated. As such it allows the semiotic selection of those receptor configurations that provide cells with the minimum essential requirements for agency. The occurrence of protein misfolding makes it impossible for receptor monomers to assemble along the membrane and to sustain meaningful relationships with environmental ligands. How could a cell lineage deal with these loss-of-function mutations during evolution and restrain gene redundancy accordingly? In this paper, we will be arguing that the easiest way for bacteria clones to accomplish this goal is by getting rid of cells expressing mutated receptor proteins. The mechanism sustaining this cell selection is also occurring in many somatic tissues and its function is currently believed to counteract in vivo protein mutagenesis. Our discussion will be mainly focused on the significance and semiotic nature of the interplay between membrane receptors and the epigenetic control of gene expression, as mediated by the control of mismatched repairing and protein folding mechanisms. (shrink)

Germ cells are cross-roads of development and evolution. They define the origin of every new generation and, at the same time, represent the biological end-product of any mature organism. Germ cells are endowed with the following capacities: to store a self-descriptive program, to accumulate a protein-synthesizing machinery, and to incorporate enough nourishment to sustain embryonic development. To accomplish this goal, germ cells do not simply unfold a pre-determined program or realize a sole instructive role. On the contrary, due to the (...) complexity of their cytoarchitecture and the nature of the soma-to-germ interactions, they are heavily involved in processes of sign recognition and meaningful tissue exploration. At each stage of their inward migration, germ plasma membranes act as semiotic interfaces allowing cells to interact with the surrounding extracellular milieu and experience the compatibility of selected developmental sequences. The question of which signaling pathways are activated at each developmental stage does not result from a strictly predetermined program instructing germ cell stemness. Rather, each developmental sequence is an open-ended semiotic relationship explored and gradually defined during evolution by the context-dependency of specific cell-to-cell interactions. In this way, any structural and functional novelty that has emerged in the course of germ cell interactions may be interpreted as an exaptation fixed in the species genome in response to specific environmental constraints. (shrink)

The egg behaves as a prospective cell sustaining the developmental processes of the future embryo. In biosemiotic terms, this apparent teleonomic behaviour can be accounted for without referring to the exclusive causal role played by its genetic makeup. We envision two different processes that are uniquely found in the oocyte: (1) the first involves the mechanisms by which large amounts of mRNA accumulate in the ooplasm to establish the embryo axes prior to fertilization; (2) the second involves transfer of an (...) excess of maternally supplied ribosomes to the oocyte to provide the future embryo with newly synthesized proteins. In this paper, we argue that the information required to sustain embryonic development is not due to any physical properties of the zygotic DNA and the maternal mRNAs, but to their spatially and temporally ordered relationship in the zygote’s internal space. (shrink)

Este artículo establece relaciones entre el mensaje de algunos manuales de Historia del bachillerato franquista, utilizados como fuentes primarias (29 en total) y la posición política de sus autores, fueran castigados (depuración en el escalafón de catedráticos de 1935), o premiados con la convocatoria de oposiciones patrióticas de 1940 que favorecieron a los simpatizantes del golpe de Estado de 1936. Para descubrir esas trayectorias personales se recurre a fuentes secundarias. Si unos autores utilizan el manual de Historia para constatar su (...) fidelidad personal al régimen de Franco; otros, lo utilizan como salvoconducto, para marcar distancias con su pasado masón, republicano de izquierdas, catalanista. Si en autores como José Ramón Castro hay coherencia entre su producción historiográfica profesional y escolar (su fidelidad al régimen es inquebrantable), Jaime Vicens Vives o Antonio Domínguez Ortiz, como autores de manuales representan la cultura oficial (legitiman al régimen); como historiadores profesionales, la denominada cultura establecida, al distanciarse más de él y de sus valores. (shrink)

Franco Eugeni remembers Bruno Rizzi: in this brief introduction, I would like to remember an afternoon spent in “ Roma Tre ” with Bruno, since we were both Ordinary Professors at that University. We passed it doing a dense program of work for the next three years. At 6.00 pm, I left for “Roseto degli Abruzzi”. At six o'clock a.m. of the next morning, I still have the voice in my ears. A phone call from the Headmaster Ciro d'Aniello, (...) who told me " The Professor is dead" In that afternoon, Emilio Ambrisi and I went to Rome; we were stunned and desperate. Not many days later, a conference was held at the University of Teramo; it was the conference that we had prepared for Bruno, to celebrate his 60th birthday, but it was his memory. In the opening conference, Prof. Antonino Giambo, also fraternal friend of Bruno, burst into a tearful cry, which expressed in a moment, the senses of friendship and love that we all had for the missing friend! Starting from this work with Fabrizio Maturo, the study of some problems left open by the works of Eugeni and Rizzi will be investigated. Sunto Ricordo di Franco Eugeni su Bruno Rizzi: in questa brevissima introduzione vorrei ricordare un pomeriggio passato a Roma Tre con Bruno, visto che allora eravamo entrambi Professori Ordinari in quella Università. Lo passammo a fare un denso programma di lavoro per i successivi tre anni. Alle 18.00 ripartii per Roseto degli Abruzzi. Alle sei del mattino successivo, ho ancora la voce nelle orecchie, una telefonata del Preside Ciro d’Aniello, che mi diceva “ Il Professore è morto” Nel pomeriggio Emilio Ambrisi ed io ci recammo a Roma, eravamo attoniti e disperati. Non molti giorni dopo si tenne presso l’Università di Teramo un Convegno, era il Convegno che avevamo preparato per Bruno, per festeggiare i suoi 60 anni, fu invece il ricordo. Nella conferenza di apertura il prof. Antonino Giambò, anche lui, come noi, fraterno amico di Bruno, scoppiò in un pianto dirotto, che espresse in un attimo, i sensi dell’amicizia e dell’amore, che tutti noi avevamo per l’amico scomparso! A partire da questo lavoro con Fabrizio Maturo verrà approfondito lo studio di alcune problematiche rimaste aperte dai lavori di Eugeni e Rizzi. (shrink)

Comprensione, spiegazione, interpretazione : attualità della riflessione ermeneutica di Max Weber -- Oggettività dell'interpretazione e forme del comprendere : un'analisi critica dell'ermeneutica di Emilio Betti -- Comprensione dell'essere e linguaggio : Martin Heidegger e i problemi dell'ermeneutica contemporanea -- Esperienza ermeneutica e ontologia linguistica in Hans-Georg Gadamer -- I limiti dell'esperienza ermeneutica -- Il dibattito sull'interpretazione nella filosofia italiana del Novecento -- Traduzione e interpretazione nell'ermeneutica contemporanea -- Ermeneutica e scienze sociali.

Estudio bibliográfico de: / A Bibliographical Study of: D.P. Verene, Vico e il mondo anglosassone (1995); Gustavo Costa, Vico e I'Europa. Contro la boria delle nazioni (1996); Aniello Montano, Storia e convenzione. Vico contro Hobbes. (1996); E. Grassi, Arte e mito (1996); AA.VV., Studi in memoria di Ernesto Grassi, Emilio Hidalgo-Serna & Massimo Marassi eds. (1996).

Introduction: Cartographies in becoming -- The happy depression -- Integrated world capitalism -- Planetary psychopathia -- Postmediatic affect -- User's manual-- Deleuze and the rhizomatic machine -- Why is anti-Oedipus the book of the '68 movement? -- Kafka, hypertext, and assemblages -- The tantric egg -- Chaosmosis -- The provisional eternity of friendship.

This article explores the impact of the VASKhNIL conference upon the cultural policy of the Italian Communist Party and Italian communist biology, with particular attention to the period between 1948 and 1951. News of the Moscow session did not appear in the Italian news media until October, 1948, and for the next three years party biologists struggled over whether to translate the official transcript of the proceedings, The Situation in Biological Science, into Italian. This struggle reveals the complex efforts of (...) the PCI to confirm the ideological and political connection with the Soviet Union, without completely alienating significant milieus of the democratic and antifascist culture in Italy. The apparent impossibility of doing both is indicated by the fact that the project was finally abandoned in March–April, 1951. The article is divided into three sections, each focused on different actors and their response to Lysenkoism. The first section outlines the features of the PCI’s pro-Lysenko campaign, with particular regard to the intellectual militancy and organizational commitment of Emilio Sereni, head of PCI’s Cultural Commission between 1948 and 1951. The second section analyzes the reaction of the three most important figures in Italian communist biology during this period, Massimiliano Aloisi, Franco Graziosi and Emanuele Padoa. The third section interprets the decision not to publish a translation of The Situation in Biological Science as a consequence of the conflicts between PCI cultural program and the editorial policy of the left-wing publishing house Giulio Einaudi Editore. (shrink)

This article explores the impact of the VASKhNIL conference upon the cultural policy of the Italian Communist Party (PCI) and Italian communist biology, with particular attention to the period between 1948 and 1951. News of the Moscow session did not appear in the Italian news media until October, 1948, and for the next three years party biologists struggled over whether to translate the official transcript of the proceedings, The Situation in Biological Science, into Italian. This struggle reveals the complex efforts (...) of the PCI to confirm the ideological and political connection with the Soviet Union, without completely alienating significant milieus of the democratic and antifascist culture in Italy. The apparent impossibility of doing both is indicated by the fact that the project was finally abandoned in March-April, 1951. The article is divided into three sections, each focused on different actors and their response to Lysenkoism. The first section outlines the features of the PCI's pro-Lysenko campaign, with particular regard to the intellectual militancy and organizational commitment of Emilio Sereni, head of PCI's Cultural Commission between 1948 and 1951. The second section analyzes the reaction of the three most important figures in Italian communist biology during this period, Massimiliano Aloisi, Franco Graziosi and Emanuele Padoa. The third section interprets the decision not to publish a translation of The Situation in Biological Science as a consequence of the conflicts between PCI cultural program and the editorial policy of the left-wing publishing house Giulio Einaudi Editore. (shrink)

New Blackfriars, Volume 103, Issue 1104, Page 309-316, March 2022.

Today, we believe that the map is a copy of the Earth, without realizing that the opposite is true: in our culture the Earth has assumed the form of a map. In Blinding Polyphemus, Franco Farinelli elucidates the philosophical correlation between cultural evolution and shifting cartographies of modern society, giving readers an interdisciplinary study that attempts to understand and redefine the fundamental structures of cartography, architecture, and the notion of "space." Following the lessons of nineteenth-century critical German geography, this (...) is a manual of geography without any map. To indicate where things are means already responding, in implicit and unreflective ways, to prior questions about their nature. Blinding Polyphemus not only takes account of the present state of the Earth and of human geography, it redefines the principal models we possess for the description of the world: the map, above all, as well as the landscape, subject, place, city, and space. (shrink)

O tema da natureza da virtude e de sua transmissibilidade atravessa quase todos os diálogos da juventude de Platão, isto é, os considerados “diálogos socráticos”. Este adquire uma relevância central no Protágoras e no Mênon, o qual se abre exatamente com a interrogação acerca da maneira de adquirir a virtude. No curso do diálogo, a arete assume um significado eminentemente político: Mênon pergunta a Sócrates como se pode obter sucesso no campo político, como se pode adquirir reconhecimento social. A tese (...) em torno a qual se desenvolve a conversação assume a identidade de virtude e conhecimento (episteme). Todavia, a consequência que deriva da assunção desta tese, isto é, o princípio com base no qual a virtude, enquanto conhecimento, seja ensinável, é refutado por meio do célebre “argumento empírico”: a ausência de homens capazes de transmitir a sua virtude aos filhos demonstra que essa não é ensinável, e ,portanto, não é conhecimento. Sócrates propõe, então, situar na opinião correta (orthe doxa) a fonte da virtude política. Todavia, a validade do argumento empírico resulta muito incerta, uma vez que parece fundar-se na ambiguidade do significado do termo didakton, que quer dizer seja “ensinável” seja efetivamente “ensinado”. Também a tentativa de fundar a virtude na theia moira deve ser tratada com certo ceticismo. Na realidade, Sócrates alude, no fim do diálogo, à possibilidade de que exista um homem que seja virtuoso e que seja também capaz de ensinar a virtude a outro homem: este homem extraordinário é naturalmente o próprio Sócrates. (shrink)

O Teeteto de Platão é um diálogo maiêutico não propositivo. Nele, Platão não apresenta a sua própria epistemologia, mas discute as posições de alguns autores contemporâneos, entre os quais Protágoras. Ele aplica o procedimento maiêutico à doutrina protagoreana para demonstrar que uma semelhante concepção não é sustentável.

In lieu of an abstract, here is a brief excerpt of the content:The Rhetoric of Parody in Plato's MenexenusFranco V. TrivignoIn Plato's Menexenus, Socrates spends nearly the entire dialogue reciting an epitaphios logos, or funeral oration, that he claims was taught to him by Aspasia, Pericles' mistress. Three difficulties confront the interpreter of this dialogue. First, commentators have puzzled over how to understand the intention of Socrates' funeral oration (see Clavaud 1980, 17–77).1 Some insist that it is parodic, performing an (...) essentially critical function (e.g., Loraux 1986); while others claim that it is serious, in particular as an expression of Plato's political ideal (e.g., Kahn 1963).2 Adherents on both sides seem to think that the options are mutually exclusive.3 Second, commentators have had difficulty understanding why Plato would have Socrates attribute his entire oration to Aspasia (e.g., Coventry 1989, 3; Pownall 2004, 60). Most agree that this move is ironic and that it has something to do with the alleged target of the dialogue's criticism. But scholars have differed over whether the Aspasia reference is meant to implicate Pericles' funeral oration (Monoson 1998), rhetoric in general (Pownall 2004), Athens (Loraux 1986), or even Aeschines (Clavaud 1980).4 Third, scholars have struggled to make sense of the dialogue's "deliberate and fantastic anachronism" (Dodds 1990, 24). In the funeral oration, Socrates relates the history of Athens up to the King's Peace in 386 B.C., a full thirteen years after he has died. This problem has generated the least consensus, with some scholars restricting their analysis [End Page 29] to dating considerations (e.g., Dodds 1990) and at least one speculating that Socrates speaks in this dialogue as a ghost (Rosenstock 1994).5It is the contention of this article that, by understanding the rhetoric of parody in the Menexenus, one can resolve these difficulties and come to a coherent and unified understanding of the philosophical intentions of the dialogue.6 More specifically, I will show that the anachronism is a consequence of a particular parodic strategy, that of amplification; that the dialogue's parody targets not only Pericles' funeral oration in particular but funeral oratory, rhetoric, and Athens as well; and that the parody has serious philosophical implications.7 Further, I claim that the serious philosophical content is both critical and constructive. Plato subverts the civic identity and understanding of virtue encouraged by the genre of funeral oration, and he challenges its praise-based model of political discourse. At the same time, Plato's parodic criticism is not entirely negative, for it relies on alternative paradigms of civic identity, virtue, and political discourse.I. The Rhetoric of ParodyBefore turning to the Menexenus itself, I want to clarify what I mean by parody. For a working definition, I suggest that parody is "an imitation that distorts a target text, author, or genre."8 In order to make some general observations about the rhetoric of parody, I will look briefly at an exemplar of parody from Aristophanes' Frogs. I do so for three reasons: to display two strategies of parodic distortion, to show that parody can have multiple targets, and to argue that parody can have both serious and complex intentions.9In the Frogs (1331–63), Aristophanes uses at least two techniques of parodic distortion, inversion and amplification, in his extended parody of Euripides' monodies or single-actor odes.10 Parodic inversion, broadly speaking, upsets or overturns the target text by distorting the original in a way that reverses the stylistic effect or semantic intention. Parodic amplification hones in on one aspect of the target text and amplifies it to absurdity, often exposing its artificiality as a literary trope.The parodic scene features a woman who awakens, hysterical and terrified, from a god-sent dream, which has conveyed disturbing news. We find in this passage a particular kind of parodic inversion: bathos, the unexpected introduction of the vulgar, ordinary, or mundane, which undermines an otherwise somber tone.11 Consider the following excerpt:Attendants, set alight a lamp for me,Collect the dew of rivers in pitchers [End Page 30] And heat the water,So that I may wash away the god-sent dream.Oh god of the sea... (shrink)

Concatenation, conjunction, and connection -- The sensitive infosphere -- Global skin : a trans-identitarian patchwork -- The aesthetic genealogy of globalization -- Language, limit, excess -- Avatars of the general intellect -- The swarm effect -- Social morphogenesis and neuroplasticity -- The transhuman -- The horizon of mutation -- Consciousness and evolution -- The end.

Our goal is to prove that the golden section, however important, is not the only key to understand a mathematical-formalizing approach to the idea of beauty. Having developed, from this point of view, reading keys linked to the post-modern, it is necessary to link together the multiple rivulets of knowledge that gather in this direction. Moreover the canons of the approaches presented up to now are very indicative for the understanding of many aspects of beauty, which however depends on the (...) historical moment and the cultures created in the various civilizations. Therefore we can affirm that there is no effective definition of "beauty" that can be codified through fixed canons, but that the concept is expressed by a series of stratifications and interpretations that tend to link several major variations, expressing the various answers given by man to the question: what is the beauty? (shrink)

Biological and Neuroscientific Foundations of Philosophy is an authoritative text addressing both academicians and students, and proposes an integrated and holistic view of scientific study and presents a new paradigm by which to study philosophy. It highlights, in a systematic and sufficiently simple manner, the fundamental role of neuroscience, neuropsychology and biology within philosophical reflection.